Assoc. Prof. Dr. Ibrahim YAMAN
Moleküler Biyoloji ve Genetik
Kuzey Park, 301
34342 Bebek - Istanbul
+90 (212) 359 7557
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Molecular mechanisms underlying carcinogenicity of mycotoxins
Studies in Molecular Toxicology and Cancer Research Laboratory (MTCRL) focus on the toxic and carcinogenic effects of food-born or other natural chemical agents. Among these agents, mycotoxins which are secondary metabolites produced by fungi pose great risks and hazards to human and animal health. The most important chronic effect of many mycotoxins is the induction and/or promotion of cancer, especially in the liver and kidney. Their carcinogenic potential are examined at the molecular level. In this context, the effects of mycotoxin Ochratoxin A on cellular signal transduction pathways, cell death and survival processes, protein degradation mechanisms such as proteasome and autophagy are examined. In a second line of work, the effects of chemical agents on gene expression are studied at the levels of transcription and translation.
- Akpinar HA, Kahraman H, and Yaman I (2019) Ochratoxin A sequentially activates autophagy and the Ubiquitin-Proteasome System. Toxins (Basel), 11(11). doi:10.3390/toxins11110615.
- Özcan Z, Gül G, and Yaman I (2015) Ochratoxin A activates opposing c-MET/PI3K/Akt and MAPK/ERK 1-2 pathways in human proximal tubule HK-2 cells.
Arch Toxic. 89(8):1313-27. doi: 10.1007/s00204-014-1311-x.
- Majumder M, Yaman I , Gaccioli F, Zeenko VV, Wang C, Caprara MG, Venema RC, Komar AA, Snider MD, and Hatzoglou M. (2009) The hnRNA-binding proteins hnRNP L and PTB are required for efficient translation of the Cat-1 arginine/lysine transporter mRNA during amino acid starvation.
Mol Cell Biol. 2009, 29(10):2899-912.
- Lopez AB, Wang C, Huang CC, Yaman I, Li Y, Chakravarty K, Johnson PF, Chiang CM, Snider MD, Wek RC, and Hatzoglou M. (2007) A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation. The Biochemical Journal, 402(1), 163–173. https://doi.org/10.1042/BJ20060941
- Fernandez J, Yaman I, Huang C, Liu H, Lopez A B, Komar A A, Caprara M G, Merrick W G, Snider M D, Kaufman R J, Lamers W H, and Hatzoglou M (2005)
Ribosome stalling regulates IRES-mediated translation in eukaryotes, a parallel to prokaryotic attenuation.
Mol. Cell. 17(3):405-16.
- Hatzoglou M, Fernandez J, Yaman I, Closs E. (2004) Regulation of cationic amino acid transport: the story of the CAT-1 transporter.
Annu Rev Nutr 24:377-99.
- Fernandez J, Lopez AB, Wang C, Mishra R, Zhou L, Yaman I, Snider MD, Hatzoglou M (2003) Transcriptional control of the arginine/lysine transporter, cat-1, by physiological stress.
J Biol Chem. 278(50):50000-9.
- Yaman I*, Fernandez J*, Liu H, Caprara M, Komar AA, Koromilas AE, Zhou L, Snider MD, Scheuner D, Kaufman RJ, Hatzoglou M. (2003) The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader. (*Equal contribution)
Cell 2003, 113(4):519-31.
- Yaman I, Fernandez J, Sarkar B, Schneider RJ, Snider MD, Nagy LE, Hatzoglou M (2002) Nutritional control of mRNA stability is mediated by a conserved AU-rich element that binds the cytoplasmic shuttling protein HuR.
J Biol Chem. 277(44):41539-46.
- Fernandez J, Yaman I, Sarnow P, Snider MD, Hatzoglou M. (2002) Regulation of internal ribosomal entry site-mediated translation by phosphorylation of the translation initiation factor eIF2alpha.
J Biol Chem. 2002, 277(21):19198-205.
- Fernandez J, Yaman I, Merrick WC, Koromilas A, Wek RC, Sood R, Hensold J, Hatzoglou M (2002) Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2alpha phosphorylation and translation of a small upstream open reading frame.
J Biol Chem. 277(3):2050-8.
- Fernandez J, Yaman I, Mishra R, Merrick WC, Snider MD, Lamers WH, Hatzoglou M (2001) Internal ribosome entry site-mediated translation of a mammalian mRNA is regulated by amino acid availability.
J Biol Chem. 276(15):12285-91.