Assoc. Prof. Dr. Stefan H. FUSS
Molecular Biology and Genetics
Kuzey Park, 319
34342 Bebek - Istanbul
+90 (212) 359 7229
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Adult Neurogenesis and Olfactory Sensory Neuron Regeneration
Olfactory sensory neurons are among the few nerve cells that are in direct and unprotected contact with the chemical environment. This unusual situation makes them vulnerable to injury and environmental insult by chemical stressors, toxicants, and pathogens. As a consequence, olfactory sensory neurons have a limited life span and only survive for for a few weeks after they are born. Thus, they need to undergo constant replacement by a process of adult neurogensis to maintain smell sensation. In addition to the maintenance of individual sensory neurons that are lost on a daily basis, the olfactory epithelium also shows a strong regenerative responses to tissue injury. Distinct neuronal stem/progenitor cells conribute to tissue maintenance under physiological and to tissue repair under injury conditions. We aim to understand the molecular signals and selective stem cell properties that contribute these processes using zebrafish as an experimental research model.
- Kocagöz Y, Demirler MC, Eski SE, Güler K, Dokuzluoglu Z, and Fuss SH (2022)
Disparate progenitor cell populations contribute to maintenance and repair neurogenesis in the zebrafish olfactory epithelium.
Cell and Tissue Research, 2022, 388(2):331-358. doi: 10.1007/s00441-022-03597-x.
- Calvo-Ochoa E, Byrd-Jacobs CA, and Fuss SH (2021)
Diving into the streams and waves of constitutive and regenerative olfactory neurogenesis: insights from zebrafish.
Cell and Tissue Research, 383(1):227-253. doi: doi: 10.1007/s00441-020-03334-2.
- Demirler MC, Sakizli U, Bali B, Kocagöz Y, Eski SE, Ergönen A, Alkiraz AS, Bayramli X, Hassenklöver T, Manzini I, and Fuss SH (2020)
Purinergic signalling selectively modulates maintenance but not repair neurogenesis in the zebrafish olfactory epithelium.
FEBS Journal, 287(13):2699-2722. doi: 10.1111/febs.15170.
Editor's choice / Cover illustration
- Bayramli X, Kocagöz Y, Sakizli U, and Fuss SH (2017)
Patterned arrangements of olfactory receptor gene expression in zebrafish are established by radial movement of specified olfactory sensory neurons.
Scientific Reports, 7:5572, doi:10.1038/s41598-017-06041-1
- Fuss SH, Zhu Y, and Mombaerts P. (2013)
Odorant receptor gene choice and axonal wiring in mice with deletion mutations in the odorant receptor gene SR1.
Molecular and Cellular Neuroscience, 56:212-224.
- Fuss SH. and Ray A. (2009)
Mechanisms of odorant receptor gene choice in Drosophila and vertebrates.
Molecular and Cellular Neuroscience, 41:101-112.
- Bozza T, Vassalli A, Fuss S, Zhang JJ, Weiland B, Pacifico R, Feinstein, P, and Mombaerts P (2009)
Mapping of Class I and Class II Odorant Receptors to Glomerular Domains by Two Distinct Types of Olfactory Sensory Neurons in the Mouse.
- Fuss SH, Omura M, and Mombaerts P (2007)
Local and cis effects of the H element on expression of odorant receptor genes in mouse.